XtalPi MicroED

Drug Solid State Development
MicroED Service For Crystal structure determination

MicroED enables rapid crystal structure determination in the absence of single crystals

XtalPi has developed a highly automated MicroED crystal structure analysis platform, which is capable of achieving high-precision crystal structure determination in as little as one day. This innovative platform eliminates the need for single crystal cultivation and only requires a small amount (several milligrams) of powder sample. To date, we have successfully completed crystal structure determination on over 100 small-molecule drugs.

It is equipped with cutting-edge instrumentation such as a ThermoFisher Scientific Glacios 200 kV Cryo-Transmission Electron Microscope, a Ceta-D camera, Falcon 4 Direct Detection Camera, and a Vitrobot Mark IV System for specimen preparation. Additionally, our solid state laboratory is equipped with the latest instrumentation for structure determination and characterization.

Applications

Crystal structure determination
Salt or cocrystal determination
Absolute configuration determination
Mixture structure analysis
Structural isomer determination

Testing Process

Powder Sample
Cryo Sample Preparation
Cryo-TEM test
Diffraction Data Collection
Structure Determination

Service Introduction

MicroED: Introduction
MicroED: Case study

Facilities and Instrumentation
Our MicroED facility boasts state-of-the-art instrumentation such as a Glacios 200 kV cryo-TEM from ThermoFisher Scientific, a Ceta-D detector specifically designed for MicroED, and a Falcon 4 direct electron detector. Furthermore, our vitrobot enables rapid and precise sample preparation for cryo-EM experiments. With these advanced instruments, we are able to perform top-notch research and provide precise outcomes.

Electron Microscopy

Vitrobot

MicroED Service For Crystal structure determination

MicroED enables rapid crystal structure determination in the absence of single crystals

Service Introduction