To create the most effective humanized mice it is crucial to incorporate as many human VH/VL genes as possible, prefera-bly within the mouse VH/VL loci, in order to closely replicate the natural immune response.
The ImmuMab® mice achieve just that with the proprietary MASIRT® technology. ImmuMab® represents the largest genetic humanization ever achieved in mouse immunoglobulin variable loci (in situ).